Fleming 625mg

Active ingredients and class: Each tablet provides 500 mg of amoxicillin and 125 mg of clavulanic acid, forming a penicillin‑class combination (co‑amoxiclav); amoxicillin kills susceptible bacteria by inhibiting cell‑wall synthesis, while clavulanic acid blocks beta‑lactamase enzymes that would otherwise inactivate amoxicillin, extending its spectrum.​

Main therapeutic uses: Used for acute and chronic respiratory tract infections (sinusitis, otitis media, bronchitis, pneumonia), urinary tract infections (cystitis, pyelonephritis), skin and soft‑tissue infections (including cellulitis and bite wounds), some dental infections, and other infections caused by susceptible organisms.​

Typical adult dosing: Common adult regimens are 625 mg every 8–12 hours (often 1 tablet twice daily or three times daily) for 5–14 days depending on infection site and severity; course length and adjustments for kidney or liver impairment must be determined by a prescriber.​

Common side effects: Diarrhoea, nausea, vomiting, abdominal discomfort, skin rash, thrush, and headache are frequently reported; more serious but less common reactions include allergic reactions (up to anaphylaxis), liver enzyme elevations or hepatitis, and antibiotic‑associated colitis, which need prompt medical attention.​

Key precautions: Contraindicated in patients with a history of severe penicillin or beta‑lactam allergy; doses may require adjustment in renal or hepatic impairment, and the full prescribed course should be completed to reduce resistance and relapse.